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Oceanic zone Intertidal Neritic zone zone ECOSYSTEMS 423 440 14 Malfunction of Signaling Pathways and Tumorigenesis Errors in Regulation of the Phosphorylation Status of pRb Phosphorylation of pRb is mainly controlled by the system of G1-specific CDKs, the D and E type cyclins and the CKIs, with the cyclinCKI relationship being of particular importance (see Chapter 14).

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